Closing in on the New Coronavirus

By Tim Vernimmen

Knowable Magazine

It is new, but not entirely. The coronavirus upending the world right now is so similar to the severe acute respiratory syndrome (SARS) virus of 2002–03 that virologists opted to simply call it SARS-CoV-2.

Yet there seem to be some crucial differences between the virus that caused an epidemic 17 years ago and the one causing a global pandemic today. The good news is that relative to the number of infections, the virus does not seem to be quite as deadly as the earlier SARS virus was. SARS-CoV-1 infected around 8,000 people and killed roughly 1 in 7, whereas the estimated death rate for known cases of SARS-CoV-2 — while still uncertain — is much lower, perhaps even less than 1 in 70.

The bad news is that SARS-CoV-2 already has spread far more widely that SARS-CoV-1 did, in part because of the milder symptoms that many people experience and the virus’s longer incubation period — the time between being infected and showing symptoms of illness. Those things mean that infected people are more likely to unwittingly spread SARS-CoV-2 than they were with SARS-CoV-1.

To understand the reasons for these differences, researchers are intensively studying the three-dimensional structure of the viral proteins and, in particular, the ones it uses to infect human cells and reproduce inside them. Such knowledge might offer vital clues for developing therapies and a vaccine — some of which are already being tested.

Continue to full article . . .

Picture: Centers for Disease Control / Public domain, https://commons.wikimedia.org/wiki/File:H1N1_influenza_virus.jpg

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